Police say a fight broke out shortly after midnight Sunday near Jackson and Halsted and someone in the crowd started shooting.
Police say someone fired a shot that struck 28-year-old man in the leg. He was taken to Stroger Hospital, where his condition was stabilized.
Officers pulled over a vehicle resembling what witnesses said the suspects drove away in, police said. Four people of interest inside were taken into police custody, and a weapon was recovered from the vehicle.
Police say the victim may not have been the intended target.
Sun-Times Media Wire contributed to this report.