The fire broke out in a two-story home in the 8400-block of South Seeley Avenue in Gresham just after 4 a.m., Chicago police said.
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One person was taken to Christ Hospital in critical condition.
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Chicago fire officials said later Friday morning the person remained in critical condition.
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Officials did not immediately provide any information on the victim's age or gender, and it was not clear how the fire began.
This is a developing story; check back with ABC7 Chicago for updates.