Officers responded to a residence around 4:30 a.m. Saturday in the 1900 block of Warwick Avenue in Hammond, Indiana, police said.
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One victim was pronounced dead at the scene with gunshot wounds, the Hammond Police Department said. The other victim had a gunshot wound to the shoulder and was taken to a hospital.
The deceased victim has been identified as 21-year-old Charles Stokes, police said.
The shooting happened after a family argument in the home, investigators said. It was an isolated incident and there is no further danger to the public.
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Police continue to investigate the shooting.
It was not immediately known if any arrests have been made or if any suspects have been identified.
No further information was immediately available.