Troopers called the chase off after losing sight of the suspect's car.
Police have not released a motive for the shooting. The victim was a 31-year-old man.
"I just thought maybe there was an accident, and when I heard there was actually a crime committed, it was discouraging," said Gaavin Davis, one of the motorists detoured due to the chase.
The search for the suspects who evaded state police is ongoing.