Police said at least seven people broke into Kelsey Resale Boutique just before 1:20 a.m.
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They said the group used a sledgehammer to break through the glass door and steal designer merchandise.
The suspects arrived in two SUVs, which stopped on Washington Street, in front of the store, police said.
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They were in and out of the business in under two minutes, according to law enforcement officials.
Police said an alarm alerted them to the crime, which they believe was planned due to specific merchandise.
"We place a lot of resources in solving these cases and the burglary at Kelsey's is no different," police said in a statement