The family said Sunday between 5:30 and 6:30 p.m., near 104th Street and Avenue F, four men approached them and offered to shovel snow.
Once inside the home, the family said the men tied up the parents - who are in the 60s - and threatened them with a knife.
Police said the men robbed the home and assaulted the couple's adult daughter. She was taken to Trinity Hospital for treatment.
An Area South investigation is ongoing.