Authorities tell Eyewitness News they were called to the home on United Street and Ell Road around 11:30 p.m. Thursday.
After the gunmen shot the homeowner in the kitchen, they ransacked his house and took off in an unknown vehicle.
Update on deadly home invasion
The homeowner's girlfriend was taken to the hospital. She was treated for stress and trauma related to the home invasion.
The woman was sleeping when the break-in happened.
Officials say it appears the house may have been targeted.
Deadly home invasion