Sanders announced his diagnosis in late February.
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On Wednesday, Sanders said his cancer was "advanced and aggressive."
"There were some complications, but I'm glad to be back here," Sanders told viewers.
He added: "Thank you to all the viewers at home for all the well-wishes and all the warm thoughts, and all the cards and letters, the gifts, the messages on social media. They really lifted me up during some really rough times and I really appreciate you helping me go through it."
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Sanders concluded by telling viewers: "I still have a long time to go on this whole journey that I'm dealing with, but with your help and the help of my friends here, it's going to be OK."
Sanders will also return to anchoring the 7 p.m. news on WCIU-TV.
Hosea Sanders return to air after cancer treatment