The explosion happened in the town of Allendale located in far southeastern Illinois near the Indiana border. According to the Wabash County Sheriff's Office, two people who were inside the home were flown to a Louisville trauma center.
SEE ALSO | House explosion Evansville, Indiana: Victims died of trauma, asphyxia
The sheriff's office said a group of neighbors pulled one victim out before it was engulfed in flames.
The conditions of the victims have not been released.
The Illinois State Fire Marshall is investigating.