Illinois State Police responded around 11 a.m. to reports of shots fired on inbound I-290 between South Kedzie Avenue and South Sacramento Boulevard.
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Witnesses told state police someone in a white car and someone in a black car exchanged gunfire while the vehicles were moving. Police said the white car was involved in a crash and exited at Sacramento, while the black car continued east on I-290.
No one was hurt. No one is in custody.
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The inbound Eisenhower was shut down at South Independence Boulevard for nearly three hours as investigators searched for evidence.
"When I saw the police on the expressway, I was like, 'Oh, there's an accident.' But now I'm listening to my satellite. It said that it's police activity. I was like, 'Oh, OK.' I'm trying to get home," said Monica Chestnut, a driver.
All lanes re-opened just after 2 p.m. Three weeks ago, inbound traffic on I-290 was also halted for nearly three hours after a man was shot in the stomach in his vehicle near Morgan Street.
Anyone who witnessed the shooting or has information pertinent to the investigation should call ISP at 847-294-4400.