The two-vehicle crash occurred at about 5:52 a.m., the Chicago Fire Department said. The crash closed the inbound lanes of I-57 at Halsted Street for hours before reopening after 11 a.m.
Fire officials said one woman died. A 20-year-old woman was transported to University of Chicago Medical Center in critical condition and a 25-year-old woman was transported to Christ Hospital in critical condition.
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Police have not released details on what led up to the crash.