A silver 2015 Kia was driving northbound in the center southbound lane near mile marker 248 shortly after 1:30 a.m. when it struck a 2015 a Chevrolet Corvette, police said.
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The driver of the Kia, 21-year-old Anna R. Warner of Beaverville, was killed in the crash. The driver of the Chevrolet was also killed in the crash. He has been identified as 20-year-old Suhail Saif Suhail Humaid Alder of Indianapolis, police said.
A person that was a passenger in the Chevrolet transported to Franciscan Health for non-life threatening injuries, police said.
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Police said alcohol is believed to be a factor in this crash.
All southbound lanes of I-65 were closed for about seven hours for crash cleanup. All lanes reopened at 8:30 a.m.