Indiana State Police said the crash occurred in the eastbound lanes of the expressway near mile marker 12.
The eastbound lanes were blocked to traffic at Grant Street. By 8:30 a.m., most lanes had reopened.
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One driver sustained life-threatening injuries, police said. Chopper 7HD flew above the scene showed extensive damage to the semi-trucks.
One semi was carrying energy drinks, which spilled along the roadway.
The crash has caused an eight-mile backup in the area.