Police were notified of shots fired at about 11:37 p.m. near 159th Street. Troopers responded to the scene and found a man inside a car with gunshot wounds, police said.
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The victim was transported to Advocate Christ Hospital with life-threatening injuries, police said.
Police had shut down the northbound lanes of the expressway between 159th and 167th streets. Lanes were reopened shortly before 5 a.m.
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Further details on the shooting were not immediately available.