The crash occurred at about 5:19 a.m. on I-88 at milepost 103, police said.
One vehicle was traveling westbound in the eastbound lanes when it crashed head-on into another vehicle, causing both vehicles to become engulfed in flames, police said.
I-88 wrong-way crash leaves 1 dead, 1 injured
The driver of the vehicle traveling westbound was pronounced dead at the scene. The driver of the vehicle that was struck was transported to a hospital with life-threatening injuries.
Investigators spent at least four hours at the crash site while traffic was diverted. All lanes were reopened at around 10 a.m.
Why the driver was driving the wrong way remains under investigation. A heavy fog was in the area at the time of the crash, but police have not said if that was a factor in the crash.