Green Thumb Industries opened its ninth Illinois store, and its 55th in the country, at 9 a.m. It's located at 270 N. Randall Road.
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Profits from the first day of sales will be donated to Habitat for Humanity of McHenry County.
The dispensary will offer all kinds of cannabis products, the company said.
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Illinois marijuana sales have continued to break records since being legalized, bringing in millions in tax revenue.
The state charges a variety of taxes on marijuana depending on the amount of THC, the ingredient that gets you high.