Indiana State Police said it happened on westbound I-80/94 near Ripley Street.
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At around 4 a.m., authorities got a call about a man involved in a road rage incident. That man pulled over to wait for police on I-65 about two miles south of the scene.
At the crash scene inside a car, a man was found shot dead at the wheel. State police said the suspect involved stopped and called authorities.
The victim has been identified to the Lake County Medical Examiner's Office as Mark Brant, 55, of Chesterton, Indiana. He died from a gunshot wound.
"So one of the individuals called to say he had been involved in a road rage incident," Indiana State Police Sergeant Glen Fifield said. "These two vehicles had a confrontation. The original caller is in our custody right now with detectives."
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1 killed in road rage shooting on I-80/94
"At the same time this individual was calling us to tell us he was involved in a road rage incident, we got reports of a crash that occurred on I-94, and troopers on scene determined these two were related," Fifield said.
The roadway was shut down for almost four hours for the investigation. Everything has since reopened.
Charges are still pending for the suspect, who is being held at the Lake County Jail, police said.