The victims were identified as Jaquetta A. Rogers, 29; Regina L. Rogers, 28; and her 11-month-old daughter Royaltyblue Rogers.
Firefighters were called at about 2 a.m. to the house in the 0-100-block of North Center Street. The bodies of a baby and two women were found.
A man in the house jumped from a second-story window, fire officials said.
The cause of the fire was still being investigated.