Kierra Coles, 27, was last seen on surveillance video October 2, 2018, as she was leaving her South Side home near 81st and Vernon. Police said she did not report to work that day and her car was where she last parked it with her purse, phone and lunch inside.
She was three months pregnant at the time.
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In July 2020, police suspended their investigation, saying they'd exhausted all leads.
Her father hopes the renewed plea will reach someone with information on his daughter's disappearance.
She is described as about 5-foot-4, weighs about 125 pounds and has black hair and brown eyes. Police said she has a tattoo of a heart on her right hand and another that says, "Lucky Libra" on her back.
Loved ones said they are not giving up hope that Coles is still alive.
Anyone with information is asked to call 911 or the Chicago Police Special Victim Unit at 312-747-8274.