The man, who was not wearing a life jacket, was pulled from the 59th Street Harbor on Chicago's South Side, according to a 9:08 p.m. tweet by the Chicago Fire Department.
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He was transported to the University of Chicago Medical Center. He was under water for more than 15 minutes.
The man's condition was not immediately released by officials.
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The victim fell from a jet ski while "partying," according to a fire department tweet.
In a tweet, the fire department urged jet ski users to wear life jackets.