Two unidentified men, about 25 to 30 years old, were found unresponsive in an alley in the 800-block of West Belmont Avenue just before 6:45 a.m. They were pronounced dead on the scene, Chicago police said.
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A woman in her 20s was taken to Illinois Masonic Hospital in critical condition, Chicago fire officials said.
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Witnesses said paramedics performed CPR on the woman, and may have revived her with Narcan, which is a medication used to reverse an opioid overdose in an emergency situation.
CPD detectives are conducting a death investigation, pending autopsy results.
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Officers remained on the scene until about 11 a.m.