The jackpot is the largest in Mega Millions history and has a cash option of $513 million.
The winning numbers for Tuesday's drawing were: 3-45-49-61-69 Mega Ball: 9
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California lottery officials said a ticket with five or six winning numbers was sold in San Francisco.
The grand prize has grown so enormous because no one has won the jackpot since July 24 when a group of 11 California co-workers shared a $543 million prize.
The previous record jackpot in Mega Millions was a $656 million prize that was shared by winners from Kansas, Illinois and Maryland in March 2012.
Mega Millions jackpots start out at $40 million and roll over if there is no jackpot winner. Overall odds of winning the jackpot 1:302,575,350.
Mega Millions tickets are sold in 44 states plus the District of Columbia and the U.S. Virgin Islands.
The Mega Millions jackpot is not the only big jackpot up for grabs this week. The jackpot for Wednesday's Powerball drawing is up to $345 million.