Police responded about 11:15 a.m. to the 6400-block of Mississippi Street in Merrillville for a reported gunshot victim.
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When officers arrived, they found a male victim who had been shot near the Menards entrance.
He was later flown to a Chicago-based hospital, where he is listed in critical condition, police said.
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Police also found a female victim who had been shot and killed in the area.
No further information on the victims was immediately released.
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Police said they were not Menards employees.
Anyone with information is asked to contact Merrillville police.