According to authorities, the body of Christine Englehardt was found last Thursday. Surveillance cameras from the Albion Hotel in South Beach show her with the two men around 1 a.m. that morning.
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Evoire Collier, 21, and Dorian Taylor, 24, both of North Carolina, were arrested over the weekend and charged with sexual battery and burglary. They are currently being held without bond.
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The men are also accused of stealing her cell phone, cash and credit cards once Englehardt was unconscious, according to a judge.
Samantha DiFrancesco, a close friend of Englehardt's, said she was a "genuinely good person."
"She was the person you brought in that lit up the whole room. Her laugh was the most contagious laugh," said DiFrancesco.
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Investigators believe Englehardt made contact with the suspects in a restaurant. One investigator said that a court surveillance video shows the suspects holding the victim up and that the video made it clear she was unable to consent.
"This is the last person I would ever think this would happen to. It just breaks your heart when you know she was a genuinely good person who would do anything for anybody. To think she went through what she went through, it's sickening; it's sick," DiFrancesco said.
Investigators believe the suspects gave the victim a green pill to drug her. The medical examiner has not made a ruling on the cause of death as toxicology results are pending, officials said.
If investigators find the pill led to her death, the suspects could face manslaughter or murder charges.