CDPH said some of the recent cases involve individuals who recently traveled to Europe. One Chicago resident also reported attending the International Mr. Leather (IML) conference in Chicago from May 26 to30.
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CDPH officials said residents from another state who were diagnosed with monkeypox also reported attending the same conference.
Chicago public health officials said they have contacted other public health departments around the country to request notification of any additional cases in people who visited Chicago from May 26 to 30.
CDPH said individuals attending festivals or other summer events should consider how much close, personal, skin-to-skin contact is likely to occur at the events they plan to attend.
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Chicago and Illinois public health officials confirmed the first probable case of monkeypox in the state in early June in an adult male Chicago resident who recently traveled to Europe.
"Chicago being a very large international hub for travel," said Dr. Irfan Hafiz, chief medical officer for Northwestern Medicine Northwest Region. "It was inevitable that we would see a case or two, possibly more, in Chicago."
Unlike COVID-19, which is a new virus, monkeypox has been around since the 1950s and the majority of cases come from central and west Africa.
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"Even though it's not likely to be transmitted to a large number of people like COVID, the people that get it can be pretty sick," said Dr. John Segreti, an epidemiologist at Rush University Medical Center.
Symptoms include rashes, sores and lesions that often look severe, as well as fever and muscle aches.
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Doctors say monkeypox is generally spread by skin-to-skin contact, though it can also be passed through contaminated clothing or bedding. And while it can make patients very sick, it is not usually fatal.
Doctors say the smallpox vaccine generally works to protect from monkey pox, and there are also anti-viral drugs on the market to treat the virus once a patient has it.
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"You're not gonna get if from walking past someone or seeing them on a bus," Segreti said. "You have to have very close contact with someone."
Public health officials say there is very little to no risk to those who have not been in close physical contact with a monkeypox patient.
"I don't think we'll see a lot of cases, but maybe a few dozen cases," Segreti said.
Most monkeypox patients experience only fever, body aches, chills and fatigue. People with more serious illness may develop a rash and lesions on the face and hands that can spread to other parts of the body. No deaths have been reported in the current outbreak beyond Africa.
Unlike with COVID-19, the chance of asymptomatic spread of monkeypox is considered low.