The man was driving a 2013 Harley Davidson traveling southbound on Route 41 north of Route 173.
A preliminary investigation determined that the motorcycle rear-ended a 1985 Pontiac Fiero, which was also traveling southbound Route 41. The 63-year-old man driving the Fiero was not injured, police said.
The motorcyclist, who was not wearing a helmet, was ejected and sustained significant injuries.
The victim wasn't immediately identified.