Nicole Daniels, 29, was taken to jail after a long morning at the Harris County Sheriff's Office detectives bureau.
Detectives say the woman offered conflicting versions of what happened inside the home on Cranberry Trail, just off the Hardy Toll Road.
According to records, Daniels was accused over the years of reckless bodily injury to a child and theft. The last time she stood for a mugshot was back in 2013, with the earliest dating back to 2005.
MUGSHOTS: Nicole Daniels had history of accusations against her
Deputies said it was Daniels who dialed 911 early Sunday morning, reporting her 67-year-old uncle Robert Mitchell was in need of medical attention.
She allegedly claimed he was intoxicated and was pushing around her children, whose ages range from 1 to 9 years old.
In retaliation, the niece alleges she pushed her uncle back and he fell to the floor.
Harris County Pct. 4 deputies rushed to the home, and found the man covered in blood. He was taken to the Houston Northwest Medical Center, but died before he could get there.
Man's killing plays out as 4 young children hide in closet
During the traumatic ordeal that ended in her uncle's death, the woman's four children were forced to take shelter, locking themselves in a closet.
Deputies said the children are OK but were understandably shaken by the violence.
The victim appeared to have three puncture wounds, but investigators did not find a knife inside the home.
A couple who was inside the home at the time of the incident told deputies they didn't witness what happened.
Man's killing plays out as 4 young children hide in closet