There were three vehicles involved in the incident, Niles police said.
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A Honda sedan, Nissan sedan and Niles police SUV crashed just before 7:20 p.m. at the intersection of Caldwell Avenue and Gross Point Road, police said.
Police did not immediately provide any additional information about what led up to the crash.
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An ambulance brought the man who was driving the Honda to a local hospital in critical condition, police said.
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A Niles officer was also taken to a local hospital with non-life threatening injuries, police said.
The woman driving the Nissan refused medical treatment.
No one else was involved.
Illinois State Police are investigating the incident.