The crash happened n the 600-block of N. Wabash just after 7:45 p.m., according to police.
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A male driver in a black 2012 Chevy sedan was traveling eastbound on Ontario when it struck a Toyota Prius in traffic. The Chevy sedan then struck four pedestrians that were standing on the corner of the sidewalk, police said.
A 26-year-old woman was transported to Northwestern Memorial Hospital in critical condition. A 30-year-old man and a 28-year-old woman were transported to the same hospital in good condition.
A fourth pedestrian, another 30-year-old man, was transported to Stroger Hospital in good condition.
The driver of the Prius, a 30-year-old man, as well as the 30-year-old female passenger, were also taken to the hospital in good condition, officials said.
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Two men and a woman in the Chevy fled from the scene and are not in custody, police said.
The Major Accidents unit is investigating.