The ramp from Woodhaven Road eastbound to I-95 southbound is blocked as the truck remains on its side.
RAW VIDEO: Tractor-trailer hauling vodka overturns
It happened around 4:45 a.m. Thursday in Cornwells Heights.
Action News is told the truck was carrying boxes of bottles of Tito's Vodka.
Some boxes fell out of the truck and onto the roadway.
Drivers should take Street Road as an alternative route.
Overturned truck shuts down busy I-95 ramp