It happened around 4 p.m.
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According to police, the victim's grandson and his two friends were playing with a gun in a second-floor bedroom when the weapon discharged and hit the woman who was in a wheelchair on the first floor.
The woman was rushed to an area hospital after being shot in the head. She is currently listed as stable.
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"This could have been very tragic. You got a grandmother sitting in her living room just enjoying the day and takes a bullet through the floorboards," said Capt. John Walker with the Philadelphia Police Department.
It's still unclear who fired the weapon.
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Police say all three teenagers are over the age of 18. One of the teens fled the scene before officers arrived. Two others are being questioned by police.
A handgun believed to be used in the shooting was recovered by officers.