It happened in the area of Germantown Avenue and W. Logan Street shortly after 8 a.m. Wednesday.
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SEPTA officials say there was an altercation between two passengers on a Route 23 bus.
They say one passenger stabbed the other in the face with a screwdriver and then fled on foot.
The 19-year-old victim received a cut to his lip. He told authorities that he did not know the assailant.
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Police have released surveillance images of the suspect as the search for him continues.
SEPTA: Bus passenger stabbed in face with screwdriver