The crash occurred at about 11:51 p.m. in the 8300-block of South Stony Island Avenue.
Police said the squad car was responding to a call with its lights activated when a silver sedan did not yield at an intersection, leading to a crash.
Two officers were transported to a hospital, where they were listed in good condition, police said.
No other injuries were reported. Police said a person was taken into custody and charges and citations are pending.
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