The fire broke out at around 3 a.m. in the 9600-block of South La Salle Street.
Firefighters arrived on the scene and extinguished the fire, police said.
A 65-year-old man was found unresponsive inside the home and pronounced dead at the scene, police said.
No additional injuries were reported.
CPD said it is conducting a death investigation.The cause of the fire is under investigation.