ISP said troopers responded to a crash on southbound I-294 near Halsted Street in South Holland just before 3 a.m.
A Hyundai Tuscan struck a Ford Bronco head-on, and both drivers were taken to local hospitals with serious injuries, ISP said. Chopper 7 was over the scene.
The left three lanes were temporarily closed for an investigation, with traffic getting by in the right lane. All lanes reopened just after 7:15 a.m.
ISP did not immediately provide further information about the crash