It happened around 8:30 a.m. during the morning commute.
One of the victims, a 39-year-old man, was riding a stand-up motorized scooter and the other victim, a 35-year-old man, was on a bike.
They were heading in opposite directions when they collided.
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EMS responded to the scene and took both victims to Weill Cornell Surgery at New York Presbyterian-Queens where they were both pronounced dead.
The investigation is ongoing, but officials say the scooter involved in the crash should never have been on the road to begin with.
"Crashes like these are entirely preventable. Scooters that travel this quickly have no place in our bike lanes," said Ben Furnas, executive director of Transportation Alternatives. "The City Council must move forward with the 'Ride Safe, Ride Right' bill to prevent the sale of the most dangerous micromobility devices. Twenty mph is plenty for anything on New York City neighborhood streets and certainly in our bike lanes. The data is clear: anything faster than 20 mph is especially deadly. Twenty is plenty - no matter who you are or how you're traveling, speed kills."
Few other details were released.