Police said the 73-year-old was in a Subaru and driving at a high rate of speed and slammed into a minivan near Black and Essington roads at about 4:18 p.m.
She then hit two more cars before her Subaru rolled over, police said.
The woman was sent to the hospital with life-threatening injuries.
Two others, including a child, were also transported to the hospital with non-life-threatening injuries.