ISP said troopers responded to the two-vehicle crash at 25th Street, near Broadview, just before 11:15 a.m.
One person was pronounced dead on the scene, ISP said. Five others were hospitalized, and their conditions were not immediately known.
ISP said traffic is being diverted onto 17th Avenue as they investigate.
What led up to the crash was not immediately clear.
Authorities did not immediately provide further information.