ISP said the four-vehicle crash happened on the ramp to near 111th Street at about 7:40 p.m.
Police believe the crash is connected to shots that were fired somewhere between 79th Street on the Dan Ryan Expressway and Halsted Street on I-57.
Three people were transported to a local hospital with injuries from the crash. ISP did not immediately provide information about the conditions of those injured.
Further information was not immediately available.
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