The single-car crash occurred just before 2 a.m. in the northbound lanes of U.S. 41 near Deerpath Road.
Police said a silver Mazda 3 sedan was traveling north on Route 41 at a high rate of speed when after crossing Deerpath, the Mazda veered off the road and rolled over at least once.
One person was ejected from the crash and two others had to be extracted, police said. All three were transported to Condell Hospital with significant injuries, police said.
Police said alcohol and excessive speed are suspected to be involved in the crash.