It weighs more than 300 pounds and is worth $7 million.
The cocaine was hidden inside a semi truck.
Police recovered it Saturday in a traffic stop southwest of Indianapolis, on Interstate 70 in Putnam County.
SEE ALSO: 2 Mississippi sheriffs, 12 officers charged in drug trafficking bribery scheme
Two men were arrested and charged with dealing narcotics; they're now being held on U.S. Immigration and Customs Enforcement deportation orders.
They were identified as Gurpreet Singh, 25, of Fresno, California and Jasveer Singh, 30, of Santa Clara, California.
The truck was traveling from Joplin, Missouri to Richmond, Indiana, police said.