The crash happened around 7:16 p.m. on Interstate 355 near Boughton Road in Woodridge, Illinois State Police said.
The crash involved two semis and a passenger vehicle, state police said. One of the semis and the car rolled over.
All northbound lanes on I-355 were shut down after the crash.
Three people were taken to hospitals after the crash, state police said. Their conditions were not immediately known.
No further information about the cause of the crash was immediately available.