The crash took place about 10:45 a.m. on I-94, north of Dundee Road in Northbrook, police said.
Five vehicles were involved. It's not clear what led up to the crash.
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One person was taken to a local hospital, and later died, police said.
All northbound lanes closed just before 11:15 a.m. They reopened about 5:45 p.m.
Illinois State Police continue to investigate.