Police said a speeding van crashed into a wall and flipped over in the 600-block of North Lake Shore Drive around 3:30 a.m. Friday.
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Six people were taken to Northwestern Memorial Hospital, Advocate Illinois Masonic Medical Center and Presence St. Joseph Hospital, the Chicago Fire Department said.
Three people were listed in serious-to-critical condition and three other were listed in fair-to-serious condition. No further information about the victims was released.
Investigators are looking into what caused the crash.