According to the organization, the reptile, identified as an approximately 8-foot-long Burmese python, had taken shelter beneath the floor of a shed.
The rescue effort required assistance from a local contractor, who helped remove floorboards so responders could safely access the animal.
Trained animal control officers then carefully removed the python from underneath the structure, taking precautions to avoid injury to both the snake and rescuers.
Video also showed a large bulge in the middle of the snake's body.
Veterinary staff at the Monmouth County SPCA performed X-rays and determined it had recently eaten a large opossum.
After being evaluated and cared for, the python was placed in a secure enclosure while officials worked to find an appropriate long-term home.
The SPCA said it partnered with reptile specialists at F&F to arrange placement with an experienced snake handler who has the proper permits and facilities to care for the animal. If no legal owner comes forward, the python will remain in permanent care with its new caretaker.
The organization is using the incident to remind owners that exotic pets should never be released into the wild.
"Exotic pets do not belong in the wild," the Monmouth County SPCA said in its social media post. Officials noted that released animals can threaten native wildlife, pose risks to pets, and often struggle to survive on their own.
Anyone who can no longer care for an exotic reptile is encouraged to contact a licensed rescue organization or animal shelter for assistance rather than releasing the animal into the environment.