All inbound Interstate 94 lanes were shut down around 2:30 a.m. near 159th Street in South Holland.
ISP troopers were searching the roadway for bullet casings at multiple locations between 130th and 159th streets.
ISP said the shooting victim is a female of an unknown age. She was hospitalized in an unknown condition.
Lanes reopened by 9:15 a.m.
So far, no one is in custody.
Authorities did not immediately provide further information about the shooting.