The foul ball hit by Cubs outfielder Albert Almora Jr., appears to have gone just beyond the net, striking the child in the stands.
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Astros players appeared shaken after the incident, and a teary Almora was consoled on the field by Cubs manager Joe Maddon.
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One Astros fan said on Twitter the child was rushed out of the ballpark.
The condition of the child was not immediately known.
The Houson Astros released a statement on the incident shortly after 10 p.m.