Chopper 7 was over the scene, where flames could be seen shooting from the roof of a barbeque restaurant at Central and Division in the city's Austin neighborhood.
Chicago Fire Department crews could be seen battling the flames from above.
Flames shoot from roof as Austin fire rages
CFD said there are no reports of injuries.
How the fire started was not immediately clear.
Officials did not immediately provide information on any injuries.
This is a developing story. Check back with ABC7 for updates.