Police said they were called to State and East North for the accident at about 5:35 p.m.
details about the crash haven't been released.
Police said they found a 13-year-old boy unresponsive underneath the semi-trailer.
The Will County Sheriff's Police and Coroner's Office were called to the scene.
Manhattan District 114 has canceled all after school activities Tuesday.
This comes just days after the school suddenly lost a 6th grader in a medical emergency.