The shooting occurred just after midnight Saturday on the Damen Avenue off ramp when police say someone opened fire into a van, hitting a 16-year-old boy in the arm.
Police say the driver, who was uninjured, made it to Fullerton and Western, where an ambulance responded. The boy was hospitalized with non-life threatening injuries.
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The shooting comes days after Monday's expressway shooting on the Dan Ryan, when someone opened fire on a tow truck.
This is the 28th shooting to occur this year along a Chicago expressway. State police have increased their overnight presence along expressways in response to the increase in shootings.
No other details have been released and police are continuing to investigate.